Promethazine is really an H1 receptor blocking agent. Besides its antihistaminic motion, it offers clinically practical sedative and antiemetic consequences.
When supplied concomitantly with promethazine, the dose of barbiturates ought to be decreased by at least one particular-50 percent, along with the dose of narcotics must be reduced by one particular-quarter to one-50 %. Dosage has to be individualized. Too much amounts of promethazine HCl relative to some narcotic may perhaps lead to restlessness and motor hyperactivity inside the patient with ache; these signs and symptoms usually vanish with adequate control of the soreness.
Promethazine should be used cautiously in individuals with cardiovascular disease or with impairment of liver function.
Impaired secretion from sweat glands subsequent harmful doses of drugs with anticholinergic Negative effects could predispose to hyperthermia.
Promethazine and codeine may well result in marked drowsiness or could impair the psychological and/or Actual physical qualities demanded for your performance of doubtless dangerous responsibilities, for example driving a car or functioning machinery.
Narcotic analgesics may well result in nausea and vomiting by stimulating the chemoreceptor bring about zone (CTZ); nevertheless, In addition they depress the vomiting Heart, to ensure subsequent doses are unlikely to produce vomiting. Nausea is nominal right after regular oral doses of codeine.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced.
Certain experiments to test the motion of your drug on parturition, lactation, and growth on the animal neonate were not completed, but a typical preliminary examine in rats indicated no impact on these parameters.
Treatment method of Overdose Treatment of overdosage is driven by the general clinical presentation, and contains discontinuation of Promethazine HCl and Codeine Phosphate read more Oral Solution together with establishment of appropriate therapy. Give Most important notice to the reestablishment of adequate respiratory exchange by means of provision of a patent and guarded airway as well as the establishment of assisted or controlled air flow.
Abuse and addiction are individual and unique from Actual physical dependence and tolerance. Wellbeing care vendors need to be aware that habit will not be accompanied by concurrent tolerance and indications of Bodily dependence in all addicts. Moreover, abuse of opioids can happen in the absence of correct addiction.
The average helpful dose of Promethazine for the active therapy of nausea and vomiting in youngsters or Grown ups is 25 mg.
You could e mail the positioning proprietor to let them know you had been blocked. Remember to involve Whatever you have been doing when this page arrived up as well as Cloudflare Ray ID uncovered at the bottom of the web page.
The standard helpful dose of Promethazine HCl Oral Alternative with the active therapy of nausea and vomiting in small children or Grownups is twenty five mg.
DailyMed will supply notification of updates and additions to Drug Label details currently shown on This web site by means of its RSS feed.